Summer School 2015

General information
University of Szeged, Hungary, from Sunday, May 10 to Friday, June 26, 2015 (7 weeks)
The University of Szeged is located in the heart of Hungary's third-largest city, Szeged, and is consistently ranked the top university in the country. As part of the program with the Drug Discovery Research Center, students will attend lectures by international researchers and participate in a laboratory component. Students will be guided and supervised through the practical components, where lecture material will be expanded on. The skills learned will later be used for data collection in individual projects. Each student will be responsible for construction of input, submitting calculations to the computer system, and data collection/analysis. This program will be comprised of students from North America and Europe.
As part of this program for 2015, students will take part on a research symposium.
CHM396Y0 – Research Topic Abroad
Course credit for research or field studies abroad under the supervision of a faculty member.
At least 8.5 FCEs and no more than 14.0 FCEs including at least 1.5 FCEs in 2nd year chemistry courses, or permission of the instructor.
Recommended Preparation
Knowledge of introductory physical chemistry (e. g. CHM220H or equivalent) is highly valuable, as is any previous experience with computational chemistry software or visualization software. A basic knowledge of organic chemistry is expected (e.g. CHM247H or equivalent).
Research skills and chemistry journal literacy are advantageous to successful project completion. Having Mken CHM299 will also be beneficial.
This is a Science course; BR=5.
Research supervisor
Imre G. Csizmadia is a Professor Emeritus at the University of Toronto and a Member of Hungarian Academy of Sciences. He joined the professorial staff at the Chemistry Department of the University of Toronto in 1964 and has been involved in both research and teaching since then. During the past four decades he has been a visiting professor many countries including: Canada, Argentina, japan, China, Taiwan, England, Germany, France, Spain, Italy and most extensively in Hungary. He was the first, globally, to carry out Gaussian molecular computations on an organic molecule. The ultimate goal in his computational pursuits has been to develop an extremely practical method for drug design.
Eligibility and Selection Criteria
This program is open to all science students who have completed at least 8.5 credits by the time the program begins. Participants must have completed courses in Chemistry or related science disciplines or have permission from the instructor.
 • Students should be interested in using computational chemistry software or visualization software.
 • Applicants may be invited for an interview.
Accommodations and Meals
Students will receive assistance to find and secure accommodation in apartment buildings. Students can expect to share an apartment with up to three other students but have individual rooms. Apartments typically have a kitchen, and there are grocery stores nearby.
The approximate cost of living in Szeged for the period of the program is CAD $1300, which includes accommodation and meals.
Entry Requirements for Visitors to Hungary
All students are responsible for making sure that they have the necessary travel documents to enter Hungary as visitors.
As of the time of publication (December 2013), Canadian citizens only require a passport valid for at least six months beyond their return date to enter Hungary as a visitor. Citizens of other countries may have other requirements. Information on entry requirements is available from the embassy of Hungary:
 • Hungary, Embassy of the Republic of Hungary in Ottawa. www.mfagov.hufkulkepviselet/CA/en
Note: Hungary is party to the Schengen Agreement, to students who do need a visa to enter them should only need to obtain one Schengen visa. For further information, please contact the embassy above. If applying for the Schengen visa, you Mould apply through the Hungarian embassy, Cu Hungary is the primary destination for this program.

Summer Schools in Szeged
(Natalie J. Galant)


Historic Predicament
(I. G. Csizmadia)


Similarly to the Industrial Revolution that took place 300 years ago, with the first safe and successful steam power plant, the invention of digital computers lead to a new Scientific Revolution in our lives. The significance of the computer is visible in all aspects of today's society but chemistry in general and the associated pharmaceutical industry in particular are experiencing the most dramatic change. The implies that within the Scientific Revolution which is unfolding there is a special dominance of Molecular Revolution that will change the Drug Discovery Research in a very dramatic way.
Some time ago the situation was illustrated by the following schematic figure.

It shows that most of the potential drug molecules are located somewhere else where we conduct our research. This take-home-message of this figure is quite correct. However, this figure is not to scale since the unexplored area, labelled as Universe of Organic Molecules, is considerably larger than shown in this figure.
From the following schematic figure it becomes clear that 63 order of magnitude (1070 / 107 = 1063) more drug sized molecules are unknown today. Since the ten million (107) drug sized organic molecules were produced by the whole human race during the past two centuries therefore an unbelievably long time would be needed to discover 1063 molecules by traditional techniques.



Fortunately, with computational methods, a great progress could be achieved with the use of High Performance Computers (HPC) and with big-data storage facilities. Such computer searching will produce certain seleted "lead-structures" that could be synthesized and subjected to biological testings during pharmaceutical research.
The purpose of the Summer School is to expose students to this new way of thinking and allow them to learn the computational methods to carry out such research projects in their future scientific carrier.